Colistin resistance associated with outer membrane protein change in Klebsiella pneumoniae and Enterobacter asburiae
نویسندگان
چکیده
منابع مشابه
Resistance to colistin associated with a single amino acid change in protein PmrB among Klebsiella pneumoniae isolates of worldwide origin.
A series of colistin-resistant Klebsiella pneumoniae isolates recovered from different countries was investigated in order to evaluate the involvement of the PmrA/PmrB two-component system in this resistance. Six isolates possessed a mutated PmrB protein, which is encoded by the pmrB gene, part of the pmrCAB operon involved in lipopolysaccharide modification. The same amino acid substitution (T...
متن کاملContribution of outer membrane protein K36 to antimicrobial resistance and virulence in Klebsiella pneumoniae.
OBJECTIVES Loss of outer membrane protein (Omp) is commonly encountered in multidrug-resistant Klebsiella pneumoniae. However, little is known about the association between Omp loss and virulence. In the present study, this association was investigated in K. pneumoniae. METHODS An OmpK36-deficient mutant (DeltaOmpK36) was derived from a virulent clinical isolate by targeted gene insertion. An...
متن کاملOuter membrane protein profiles of clonally related Klebsiella pneumoniae isolates that differ in cefoxitin resistance.
Eleven genotypically related Klebsiella pneumoniae isolates were obtained from 11 patients. All isolates were resistant to third-generation cephalosporins due to the production of SHV-2a extended-spectrum beta-lactamase. Comparison of the outer membrane protein profiles revealed one isolate that lacked porins. This porin-deficient isolate was also resistant to cefoxitin (MIC 128 microg ml(-1)) ...
متن کاملEvaluation of antibiotic resistance associated with ophthalmic oqxAB pumps in Klebsiella pneumoniae causing urinary tract infection
Background: The urinary tract infection is the secondary most common human infection. Colon bacteria, including Klebsiella pneumonia, are the main cause of urinary tract infections. The occurrence of the antibiotic resistance is a major problem in the treatment of infections. Beta- lactamases and efflux pumps constitute the major defense mechanisms of antibiotic resistance of Klebsiella pneumon...
متن کاملEmergence of colistin resistance in Klebsiella pneumoniae from veterinary medicine.
Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland; Unité Antibiorésistance et Virulence Bactériennes, French Agency for Food, Environmental and Occupational Health and Safety (Anses), Lyon, France; INSERM U914, South-Paris Medical School, K.-Bicêtre, Paris, France; Centre National Associé Centre de Référence des Ré...
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ژورنال
عنوان ژورنال: Acta Microbiologica et Immunologica Hungarica
سال: 2017
ISSN: 1217-8950,1588-2640
DOI: 10.1556/030.64.2017.017